FMLY 1010 Lecture Notes - Lecture 20: Congenital Disorder, Prenatal Development, Teratology

• School: University of Manitoba
• Department: Family Social Sciences
• Course: FMLY 1010
• Professor: Christine A.Schippers

Document Summary

Mutagens = agents that cause changes (mutations) in genomic dna. Causes germinal mutation interferes with conception and development of fetus. E. g. high exposure of gametes to x-rays can lead to infertility. Somatic mutations chromosomal/genetic errors that can cause congenital anomalies that can be transmitted to future generations. Direct, non-heritable effects on prenatal development by damaging cells or disrupting cell development. Cell proliferation = the increase in cell numbers by means of cell growth and division. Cell migration = movement of cells to their genetically predetermined destinations in the body. Epimutagens = agents that cause abnormal gene silencing or expression without changing the genomic dna: e. g. (cid:373)other"s diet ca(cid:374) produce e(cid:374)duri(cid:374)g cha(cid:374)ges o(cid:374) successive ge(cid:374)eratio(cid:374)s i(cid:374)depe(cid:374)de(cid:374)t of later changes in diet of the offspring. Fathers pass on average, 55 mutations to their children (mother passes 14) Production/performance of sperm contributes to infertility, miscarriage, congenital anomalies.