BIOL 2520 Lecture Notes - Lecture 14: Meiosis, Nocodazole, Spindle Apparatus

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The cytoskeleton is a series of long, filamentous protein fibers that are formed within the cell. Made of a variety of related proteins. Functions of the cytoskeleton: structural support, the cytoskeleton provides structural support that can determine the shape of the cell and resist forces that can deform the cell. A cell"s shape is closely associated with its function. Cytoskeleton can rearrange itself to change the shape of the cells. The internal exoskeleton is integrated with the external cytoskeleton. Fibroblasts, highly motile tip of a growing axon (movement is like a crawling wbc. Tubulin at one end, -tubulin at other. All protofilaments in a single microtubule (mt) have the same polarity: microtubules are therefore asymmetric and polarized, end is plus; end is minus. Tubulin dissociates from microtubule after polymerization has progressed subsequent subunit addition is faster depolymerisation also occur spontaneously, but at a slower rate.

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