BIOL 2520 Lecture Notes - Lecture 9: Hemoglobin, Progeria, Lmna
8 Dec 2017
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Messenger rna starts as a hnrna in the nucleus: heterogeneous nuclear rna (hnrna) Heterogeneous in both size and sequence, located in nucleus. Produced by rna polymerase ii; a copy of the gene. Contains intervening non-coding regions: introns, which are spliced out, forming the smaller cytoplasmic form. On average, exons are about 150 nucleotides long, introns multiple kb. As it is made, hnrna is covered by small rnas and proteins the half-life of new hnrnas is only a few minutes as they get processed into mrna. Does(cid:374)"t last lo(cid:374)g, half life of (cid:1005)5 (cid:373)i(cid:374), p(cid:396)o(cid:272)essed as it is (cid:373)ade: mrna splicing: Introns must be removed with precision: one base off and the protein is wrong. Highly conserved, recognizable sequence regions called the splice-sites (within hnrna that. Splicing is performed by a number of protein/rna molecules. Sequence of dna having similar structure and function in different organisms helps recruit splicing machinery) Consensus sequence: same for almost all genes.
