BIOL 2420 Lecture Notes - Lecture 4: Tunica Intima, Endothelium, Vascular Resistance

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The rate of blood flow (f) to tissues and organs is determined by: pressure differences between two points in the circuit ( p) Pulse pressure is the systolic pressure - the diastolic pressure: friction. Vascular resistance due to: length of the blood vessels (l, viscosity of blood ( ) The first two determine surface area in contact with blood. R=8l / r4: l is constant, is determined by: hematocrit, plasma protein. Resistance is mainly determined by vessel radius. Inverse relationship between vessel radius and blood pressure: small changes in vessel radius dramatically affects resistance, vasodilate - decrease resistance. Increases the flow - decrease the velocity: vasoconstrict - increase resistance. Blood vessels consist of: tunica intima (interna) Responsible for secreting substances that regulation blood flow. Play a role in blood clotting - release chemicals to activate platelets: elastica interna. Relaxation/contraction works to increase/decrease vessel radius: elastica externa. Varied thickness of vessels from arteries to capillaries: arterioles.

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