ZOO 3050 Lecture Notes - Lecture 1: Cellular Differentiation, Cell Adhesion, Microcephaly
13 Apr 2018
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Document Summary
Cellular differentiation: generation of cellular diversity, single cell to multi-cellular organism, specialization of cells, largely determined by changes in gene expression. Morphogenesis: creation and organization of biological, distribution of morphogens, changes in cellular structure, cell adhesion, cytoskeletal changes. Growth: regulation of cell division, number of cells, size of cells. Reproduction: sexual or asexual, separation of somatic tissue, germ line differentiation, meiosis, mitosis. Understanding of developmental processes enables study of the causes and treatments of developmental diseases i. e. link between zika virus and microcephaly. In 2016, virus transmitted from mosquitoes in southern america, affecting pregnant mothers. Decrease in formation of brain occurs in-utero, decrease in amount of brain material, leads to cognitive impairment. Most aspects of cancer are fundamentally similar to normal development: cell division, cell migration, differentiation. Regeneration uses several developmental processes in the adult i. e. amphibians, zebra fish, flat worm: de-differentiation, differentiation, cell division, cell migration.
