PSYC 4580 Lecture Notes - Lecture 8: Allosteric Modulator, Anti-Obesity Medication, Fatty Acid Amide Hydrolase
7 Nov 2017
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Chapter 7 cannabinoids, body weight, feeding and appetite. Cannabis stimulates appetite for palatable foods: cb1 receptor dependent. Treatment for cachexia: wasting disorders (loss of adipose tissue) in patients with cancer, aids, anorexia, mixed efficacy with dronabinol (synthetic thc, faah inhibitor demonstrate pre-clinical efficacy) Endocannabinoids & eating disorders foods: dysfunction of endocannabinoid system may lead to eating disorders, anorexia nervosa, dramatic weight loss, bulimia nervosa, binge eating and vomiting, compare women with eating disorders vs healthy controls, anorexia patients. Increased blood levels of aea not 2-ag: decreased leptin (accompanied by higher aea) Increased cb1 receptor in insula (important in food/reward processing: bulimia patients, no different in blood levels of aea. Increased cb1 receptors in insula: **over-activation of endocannabinoid system may be to enhance motivation for food. Endocannabinoid system regulates appetite, food preference, body weight. Dysregulation of endocannabinoid system may cause eating disorders obesity. Elevated aea and 2-ag in obese patients. Manipulations that reduce aea and 2-ag levels may be therapeutic options.
