PSYC 4580 Lecture Notes - Lecture 6: Cytochrome C Oxidase Subunit Ii, Ibuprofen, Orbitofrontal Cortex
12 Oct 2017
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Document Summary
Acute effects of cannabis on cognition in humans. Temporary impairment in: short-term memory, consolidation into long-term memory, does not impair retrieval of long-term memories. How long do these impairments persist in chronic users: that is what we are trying to find out. Recent systematic reviews of studies found: consistent findings: verbal learning and memory attention impaired, inconsistencies in finding making other conclusions. Effects of thc and cb1 agonist in animals. Does not disrupt long-term or reference memory. Endocannabinoids manipulations on leaning and memory in animals. Faah inhibition: in general, seems to facilitate working memory, but faah inhibitors elevates aea and oea and pea. Magl knock out mice: facilitates short term memory performance. Dual faah/magl inhibition: disrupt short-term spatial memory performance. High density of cb1 receptors in this region. Effects of cb1 agonists on working memory, similar to hippocampus lesions. Thc effects on working memory may be due to changes in the hippocampal functions: supressing release of glutamate in hippocampus.
