PSYC 4470 Lecture Notes - Lecture 15: Memory Consolidation, A Reminder, Fear Conditioning

• School: University of Guelph
• Department: Psychology
• Course: PSYC 4470
• Professor: Boyer Winters

Document Summary

It was believed that once a memory became consolidated it was done, but now we k(cid:374)o(cid:449) that (cid:373)e(cid:373)ories are re(cid:373)i(cid:374)ded a(cid:374)d (cid:272)a(cid:374) (cid:271)e (cid:272)ha(cid:374)ged or (cid:862)re-re(cid:373)e(cid:373)(cid:271)ered(cid:863) Nader et al. (2000) fear conditioning in the amygdala. Cs(tone)-us pairing 24 hours later (protein-synthesis is finished after about 6 hours so at this point the memory is consolidated) Test 1 (reminder) play cs briefly, measure freezing (to see if they have the memory. ++ injected with anisomycin or cerebrospinal fluid established) Test 2 what is the effect of anisomycin on reconsolidation (test 1), tested 3 trials and low- 24 hrs dose + cerebrospinal fluid = no effect, high-dose = less freezing (impaired memory) Included a no-reactivation/no-reminder condition to show that it is reminder-dependent reconsolidation that it"s not just lingering consolidation that you"re interrupting. Lee et al. (2004) doubly dissociating the roles of bdnf and zif268.