PATH 3610 Lecture Notes - Lecture 20: Intramembranous Ossification, Endochondral Ossification, Granulation Tissue

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Bones and Joints
Functions
- mechanical support
- mineral homeostasis (calcium)
- haematopoietic elements within marrow cavities
- movement and stability
- organic 35%
- inorganic 65%
- bone is alive!
- Formed from cartilage (endochondral ossification) or within fibrous tissue
(intramembranous ossification)
- Osteoblasts: once they produce bone, they are incorporated within matrix to
form osteocytes
o Produce large amount of bone
- Osteocytes: mineral metabolism and responsible for removing small amount
of bone
- Osteoclast: derived from macrophages and remove bone
- Osteons: bone present for a long time arranged in columns and is
multilayered and called lamella
- Woven or reactive bone: rapidly formed
Fractures heal this way
- bone in mesenchymal tissue
- hematoma develops around fracture
- fibrous callus
o soft tissue callus (granulation tissue) bones heal with granulation
tissue
- primary callus
o bony callus formation
- secondary callus
o remodelling and modeling
- when you heal a wound, fracture, cut each individual tissue will heal
according to its ability
- movement prevent healing injure fibroblasts that form granulation tissues
Osteoporosis
- reduced quantity of bone and the bone remaining is normal quality
o mechanical and non-mechanical factors
o disuse atrophy
disuse atrophy: body removes bone from areas where its not
required, limb immobilized because of a fracture
o gonadal insufficiency
osteoclast hyperactive - remove more bone than laid down by
osteoblast and result in weakening of all bones
hence less bone
o senility
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Document Summary

Formed from cartilage (endochondral ossification) or within fibrous tissue inorganic 65% (intramembranous ossification) Osteoblasts: once they produce bone, they are incorporated within matrix to form osteocytes: produce large amount of bone. Osteocytes: mineral metabolism and responsible for removing small amount of bone. Osteoclast: derived from macrophages and remove bone. Osteons: bone present for a long time arranged in columns and is multilayered and called lamella. Hematoma develops around fracture fibrous callus: soft tissue callus (granulation tissue) bones heal with granulation tissue. Primary callus: bony callus formation secondary callus, remodelling and modeling. When you heal a wound, fracture, cut each individual tissue will heal according to its ability. Movement prevent healing injure fibroblasts that form granulation tissues. Non mechanical or permissive factors: dietary calcium, vitamin d, amino acids, testosterone must be in adequate amounts to allow normal remodelling. A 75 year old has half the bone of a 20-30 year old.

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