PATH 3610 Lecture Notes - Lecture 4: Antigen-Presenting Cell, Lymph Node, Clonal Deletion

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

U n i t 4 : t h e i m m u n e r e s p o n s e. Skin and mucous sloughed from surfaces, remove organisms. Skin has acidic ph, lysozyme in tears, acid in stomach, digestive enzymes. Mucus secreted by membranes of tracts are act as protective coating. Inflammation nonspecific phagocytosis by neutrophils and macrophages. Immune response characterized by specificity in antigen, memory, and evoke an enhanced response on second exposure (amplification) Molecules that evoke immune response when introduced into host. Hapten: small molecules that can become antigenic if complex with larger carrier molecules. Foreign (extrinsic) antigens: infectious agents, transplanted foreign cells, other particles. Components of body can also become antigenic-- cancer cells (neoplastic) considered foreign. If cell bound by hapten, body reacts against them. Some antigens separated from immune system (lens protein in eye); no tolerance developed. Lack of response to our own antigens.