NUTR 4010 Lecture Notes - Lecture 19: Acute-Phase Protein, Oncotic Pressure, Hypoalbuminemia

• School: University of Guelph
• Department: Nutrition
• Course: NUTR 4010
• Professor: Dalia El Khoury

Document Summary

Main site for the synthesis is in the liver (also call hepatic protein) (liver is one is the first organs to be affected by protein restrictions. ) In acute illness or trauma, levels of some hepatic proteins increase while others decrease (+) positive acute phase protein levels increase (c-reactive protein, fibronectin, ferritin) (-) negative acute phase protein levels decrease (albumin, pre-albumin, transferrin, insulin. You know a pt is in an acute phase if c-reactive protein is high. Sensitivity (the lower half-life of the serum protein, the higher the sensitivity to detect changes in protein status. ) [ no malnourished person is classified as well ideally no false negatives] Specificity (serum proteins tend to have low specificity because they can be affected by many factors beside nutrition. ) [100% specific malnutrition tool no well-nourished person is classified as ill. Measure crp first to learn about inflammatory process. Then can know if blood work dus to. Most abundant serum protein 50-60% of total serum protein.