NUTR 3210 Lecture Notes - Lecture 19: Procollagen-Proline Dioxygenase, Glutathione Reductase, Glutathione Disulfide
23 Mar 2017
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Document Summary
Problem, once you use your glutathione you are left with oxidized one. 2 glutathione born a disulfide bridge when interacting. However, it lost the ability to be an antioxidant. Nadph regeneration happens in hexose monophosphate shunt: at physiological ph = ascorbate, exists in both d- and l- isomers (l-isomers biologically active in humans, many mammals can synthesize vitamin c from glucose, except: Humans, primates, fruit bats, guinea pigs, and some birds. This is because we lack specific enzyme: gulonolactone oxidase. In foods, most ascorbic acid, but small amounts of oxidized form (dehydroascorbic acid) exists. 70-90% dietary vitamin c absorbed (appears to be maximum amount of vitamin c that can be absorbed) remaining gets lost in feces, found primarily in free form : vitamin c tissue concentrations greater than plasma. Involved in a number of biological processes (collagen synthesis, tyrosine synthesis, neurotransmitter synthesis: vitamin c acts primarily as a reducing agent in these processes 2 electron donor.
