NUTR 3210 Lecture Notes - Lecture 16: Rheumatoid Arthritis, Rankl, Osteomalacia
16 Mar 2017
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Between 100 and 140 million children are vit a deficient. An estimated 250000 500000 vit a deficient children become blind every year, half of them dying within 12 months of losing their sight (who) Retinol activity equivalents (rae: 1 rae = 1 microgram dietary retinol = 12 microgram beta-carotene = 24 microgram other carotenoids. Rae accounts for differences in biological activity of carotenoids. Rda for adults: men 900 micrograms rae, women 700 micrograms rae. Why no ul for beta-carotene: carote(cid:374)oids pre(cid:448)e(cid:374)t defi(cid:272)ie(cid:374)(cid:272)(cid:455), (cid:271)ut do(cid:374)"t (cid:272)ause to(cid:454)i(cid:272)it(cid:455, (cid:1005)5,(cid:1005)5"-carotenoid mono-oxygenase regulated by vit a status, if you have enough vit a, carote(cid:374)oids are(cid:374)"t (cid:272)o(cid:374)(cid:448)erted to reti(cid:374)ol, (cid:271)ut are stored i(cid:374) adipose. Most severe consequence is liver cell death: retinyl palmitate is stored in the stellate cells of the liver and with excess vit a intake, the cells get full to capacity. Raw vit a spills out and the local hepatocytes become damaged and die.
