NUTR 3210 Lecture Notes - Lecture 18: Lipoprotein Lipase, Adipose Tissue, Lipogenesis
15 Nov 2016
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Liver: primary site for gluconeogenesis (some also occurs in the kidney, considered the primary organ regulating blood glucose, major site for fat metabolism, including lipolysis and lipogenesis, and lipoprotein assembly and degradation, only tissue to produce ketone bodies. Fatty acid mainly derived from adipose tissue is predominant source of energy. Dark meat lots of myoglobin and mitochondria: fast twitch: short duration, quick contractions. Blood glucose and muscle glycogen provide energy, may result in lactate accumulation. Storage site for tag: glucose uptake in adipose tissue is regulated by insulin. Red blood cells: organelles are lost to make room for hb (therefore no mitochondria, energy must be derived from glycolysis only. Brain: high energy needs, primarily uses glucose. Glucose just crosses the blood-brain barrier: in the fed state, the brain will catabolize only a small amount of fatty acids. In starvation, the brain will rely on ketone bodies for about 2/3 of its energy needs.
