NUTR 3090 Lecture Notes - Lecture 5: Diabetes Mellitus Type 2, Insulin Resistance, Atherosclerosis
15 Feb 2019
School
Department
Course
Professor
Document Summary
Without insulin --> go into ketoacidosis & coma. Etiology classification of dm: type 1 of pancreatic beta cell destruction and is prone to ketoacidosis. This form includes cases due to an autoimmune process and those for which the etiology of beta cell destruction is unknown. Etiology classification of dm: type 2 may range from predominant insulin resistance with relative insulin deficiency to a predominant secretory defect with insulin resistance. Increased susceptibility to infections (hyperglycemia can cause; immune dysfunction; depressed antioxidant system; decreased antibacterial activity of urine) Blindness affecting large and small vessels in your vascular system. Micro-vascular complications non-proliferative - early stages - micro aneurysms in the fundus (interior surface of the eye opposite the lens) --> no symptoms. No formation of new vessels, start to swell proliferative- later stage - new fragile blood vessels grow in the retina, leaking blood --> clouding the vision. Macro-vascular complications metabolic effects fo dm results in accelerated atherogenesis from combination of:
