MICR 4010 Lecture Notes - Lecture 3: Cytolysin, Brucella, Signal Peptide
21 Feb 2014
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Gram-positives -> tend to use the general secretory pathway (gsp) Gram-negatives -> proteins secreted have to get through the outer membrane (om) Also known as atp-binding cassette (or abc) transporters. Protein moves through im and om without stopping. For secretion of protein effectors directly into the host cell (as well as into the extracellular milieu) Translocate protein or complexes of protein + ssdna. Almost always require host-cell contact to initiate delivery. H. pylori, legionella pneumophila, brucella spp. , coxiella burnetii, bartonella spp. Transport across the om facilitated by a complex secreton. May involve a piston-like structure in the im to help push the secreted protein through. Liked to assembly of adhesive structures on the bacterial surface. Secreted proteins don"t require a signal peptide*** Thought to form a molecular spike to punch holes in host cells for secreted effectors to gain entry (like a phage tail) Used not only against the host, but against other bacterial species.
