MICR 4010 Lecture Notes - Lecture 3: Ultimate Tensile Strength, Vinculin, Doubling Time
21 Feb 2014
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Document Summary
Endothelium: blood vessel walls, lympathic system. Extracellular matrix: may secrete collagenases to allow digestion of the ecm. Organism may be capable of breaching the epithelium of its own accord. Organism is injected into the host by an arthropod. Organism gains access to the underlying tissues following trauma to the epithelium. Actually more like pathogens often behave more like confidence tricksters; the host cell usually invites them inside! Inside host cells: nutrients are abundant, no competition with extracellular bacteria, immune system is circumvented. The host cell cytoskeleton: dynamic structure: constantly being rearranged to meet the needs of the host cell, involved in: cellular movement, vesicle trafficking, mitosis, formation of a range of protrusions, 3 main components: actin filaments, microtubules, intermediate filaments. Polymer of 43kda globular protein, actin -> arranged to a form helical structure. Organized in the form of linear bundles, 2d networks, 3d gels -> actions of numerous accessory proteins.
