MICR 3230 Lecture Notes - Lecture 3: Hematopoietic Stem Cell, Cfu-Gemm, Lymphopoiesis
25 Oct 2018
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Document Summary
Hematopoietic stem cells (hscs): give rise to all the types of blood cells. Stem cells can divide asymmetrically (one is the stem cell, the other is another cell/stem cell. Rare - fewer than one per 5 x 104 cells in the bone marrow (this is where they mainly reside) Under homeostatic conditions most are quiescent only a small number divide, generating daughter cells. Some daughter cells retain the stem cell characteristics; other differentiate into progenitor cells: progenitor cells lose their self-renewal capacity and become progressively more committed to a particular blood cell lineage. Hematopoiesis is the process by which hscs differentiate into mature blood cells. Hsc differentiates into common myeloid progenitor (cmp) or common lymphoid progenitor (clp) Clp gives ride to b cells, t cells, innate lymphoid cells (ilcs include natural killer cells), and dendritic cells (lymphoid lineage) Cmp gives rise to red blood cells (erythroid lineage), granulocytes, monocytes, macrophages, and dendritic cells (myeloid lineage)
