MCB 2050 Lecture Notes - Lecture 1: Interactome, Transcriptomics Technologies, Transcriptome

• School: University of Guelph
• Department: Molecular and Cellular Biology
• Course: MCB 2050
• Professor: John Vessey

Document Summary

Genome mapping and sequencing (where specific genes are located, which chromosome/loci) The comparison of genomes of different organisms. Analysis of the transcriptome and the proteome. Uses the information from genome sequencing to describe gene and protein functions and interactions. Uses information from genome sequencing to create new or modified organisms. Genomics: study of the genome , the entire dna genetic material of an organism. Metagenomics: study of aggregate genomes from a complex of organisms (eg. from a gut microbiome) Transcriptomics: study of the transcriptome , all rnas (trnas, rrnas, snrnas, incrnas, micrornas, mrnas) in a cell. Proteomics: study of the proteome , all the proteins of an organisms and their interactions in a cell. Interactomics: study of the interactome , all interactions (eg. protein-protein, protein-nucleic acid, protein-ligand) of an organism. Genetic maps can be used to identify which gene is responsible for a genetic disease and how this gene is altered in those with the disease.