MCB 2050 Lecture Notes - Lecture 9: Endosome, Phagocytosis, Hydrolysis
Document Summary
Biosynthetic pathway: lysosomal proteins (e. g. , soluble acid hydrolyase enzymes) are synthesized & initially n-glycosylated in the rer, then transported (via copii vesicles) from eres to the golgi. In the cis golgi cisternae, glycosylated lysosomal proteins are further modified i. e. , phosphorylation of two mannose residues (m6p; mannose-6-phosphate) in the protein"s core oligosaccharide(s) If things are used and wants to be used again, they gotta be recycled from their place of origin: mvb (late endosome. Fragment") fuses with the lysosome: mvb membrane proteins move laterally into the lysosomal membrane, all mvb lumenal contents are. E. g. , pm receptors destined for degradation in the lysosome [see later] Intralumenal vesicles with plasma membrane materials (e. g. , receptors) - degraded. Endocytic pathway: operates in the opposite direction of the secretory pathways. Materials move into the cell via vesiculation of the pm and either recycled back to the pm or transported to the lysosome for degradation: two main process for internalization, endocytosis selective internalization of.