MCB 2050 Lecture 3: MCB 2050 V3
19 Mar 2017
School
Department
Course
Professor
Document Summary
Dynamic, coordinated network of all the cell"s organelles and related structures (except peroxisomes, mitochondria and chloroplasts: endoplasmic reticulum (er, golgi, endosomes, lysosomes/vacuoles, secretory granules, plasma membrane. Large amounts of material (e. g. lipids, proteins, etc. ) are exchanged (traf cked3) between each organelle/structure via small, membrane-bound transport vesicles. The organelles of the endomembrane system are structurally and functionally distinct from one another: contain a particular set of proteins, perform a unique set of activities, provides compartmentalization and functional diversity, conserved in eukaryotes, dynamic structures. Traf cking through the endomembrane system via transport vesicles. 4 general steps of vesicle transport: step 1: cargo-containing vesicle buds off the donor membrane compartment. Vesicle receptor proteins regulate the intracellular traf cking of the vesicle to the proper recipient membrane. Involves molecular motors and cytoskeleton highways i. e. motor proteins direct vesicle movement within the cell by linking to the vesicle surface to the: step 3: vesicle fuses with the proper recipient membrane compartment.
