MCB 2050 Lecture Notes - Lecture 3: Phylogenetic Tree, Affymetrix, Electrophoresis
26 Jan 2017
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Document Summary
Mining the information in the information in the genome databases using bioinformatics techniques. Bioinformatics attempts to deduce the structure/function of a gene or gene product through non-experimental (in silico) comparison of genes or genomes. Largely computer modelling of molecules based on the knowledge of sequence, structure, and function of homologues. Genome evolution: documents changes responsible for the divergence of species from common ancestors. Phylogenic trees can be constructed based on sequences comparisons, and from those, evolution can be inferred. The study of genetic nd other biological information using computer and statistical techniques. Given a nucleotide sequence: nd open reading frames, deduce amino acid sequence, nd homology to other proteins, nd common domains (dna binding, oligomerization, modi cation sites) Is the sequences i just cloned homologue to other known genes: blast to nd out! basic local alignment search tool, allows you to search genbank for similar sequences. Amino acid sequence alignments can identify proteins with related functions.
