MCB 2050 Lecture Notes - Lecture 2: Nuclear Pore, Cytosol, Ribosomal Dna

• School: University of Guelph
• Department: Molecular and Cellular Biology
• Course: MCB 2050
• Professor: Mosser/vessey

Document Summary

Nucleoid (region where the chromosome is located, not membrane-bound) Compartmentalization of the cellular genome and its activies: example: site where translation components are synthesized, example: site of dna replication, transcription and rna processing. Coordination of cellular activities: control of metabolism, protein synthesis, cell division. Nuclear envelope: nuclear membrane, nuclear lamina, nuclear pores. Nuclear content: chromatin, nucleoplasm, nuclear matrix, nucleolus. Outer membrane binds ribosomes and is continuous with rough endoplasmic reticulum. Inner membrane: contains unique protein composition distinct form outer membrane, integral membrane proteins that connect to nuclear lamina. Intermembrane space (nuclear envelope lumen) is continuous with er lumen. Inner and outer membranes join at nuclear pores. Separates nuclear content from cytoplasm: genome from cytosol, transcription from translation. Slective barrier: allows regulated passage of molecules between the nucleus and cytosol (rna and proteins can pass, establishes the composition of the nucleus and regulates gene expression. Binds nuclear lamina: provides structural framework for nucleus.