MBG 1000 Lecture Notes - Lecture 10: Peptide, Sunscreen, Dna Ligase
23 Mar 2016
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Pigment is melanin (function to colour and protect cells) Melanin synthesized in melanocytes *they produce melanin (melanocytes form cellular extensions between other skin cells, and is distributed to other skin cells) Albinism = absence of pigment (skin, hair and eyes) Tyrosine has a problem breaking down in albinism. Tyrosinase is an enzyme that plays a role in initially producing phaenomelanins (yellow/orange pigment) or eumelanins (black/brown pigment) Oculocutaneous: oculo = eyes, cutaneous = affects skin. The gene that causes albinism encodes the enzyme tyrosinase (chromosome. Phenotype is associated with the homozygous condition (often involves loss of gene function) Null amorphic alleles: 1) a non-functional protein is produced or 2) no protein is produced *you"re really messed up* Hypomorphic alleles: 1) a poorly functioning protein is produced or 2) Reduced amounts of a normally functioning protein is produced *you"re just kind of pale* Catalytic site are the amino acids do the conversion of tyrosine to the product.
