MBG 1000 Lecture 10: Examples of Recessive Traits (Part Two)
2 Feb 2017
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The phenotype for sickle cell anemia was first described by physician james herrick (1910) in chicago. The symptoms include chronic fatigue, shortness of breath, paleness, pain, infections, enlarged spleen, sores that do not heal, strokes, eye problems. Anemia is a decreased capacity to deliver oxygen to tissue; this can be brought on in two ways: a decreased number of rbcs or decreased rbc volume, or, the rbcs are deficient in hemoglobin. James herrick"s paper states that there are peculiar elongated and sickle cell shaped corpuscles in [cases] of severe anemia . The gene that causes sickle cell anemia encodes beta-globin; the beta-globin gene is on. Treatment for sickle cell anemia includes: daily anti-biotics, pain management (e. g. , frequent visits to physicians, prevention of complications, blood transfusions. Sickle cell anemia has its origins in sub-saharan africa, mediterranean countries (turkey, greece, and italy), south and central america, and the caribbean.
