FRHD 2060 Lecture Notes - Lecture 3: Diffusion Mri, Leukoaraiosis, Functional Neuroimaging
5 Apr 2018
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Document Summary
Highly detailed image of anatomical features of the brain. More interested in the activity of the brain. Compares healthy older adults with those w/pathological disorders of the brain: 2. Links measures of cognitive performance to measures of brain structure/f(x: 3. Link functional brain activity with cognitive behavior data. Brain structure: no need to memorize exact anatomy of the brain. Neurons: dendrites, axon, neurofibers, terminal branches, neurotransmitters travel across the synapse, age related changes in neurons. Decrease in number of synapses: age related changes in neurotransmitters. Brain changes: white matter hyperintensity (leukoaraiosis) Myelin sheath loss and neural atrophy: shrinkage in brain volume, enlarged ventricles. Can be viewed via structural imaging: diffusion tensor imaging (dti) Index of density and structural health of white matter. Difficulty focusing due to wmh, and reduced prefrontal cortex. Changes in the hippocampus result in memory decline. Older adults may rely on more automatic judgement processes than reflective processing.
