BIOM 4180 Lecture Notes - Lecture 5: Audio Time Stretching And Pitch Scaling, Adrenergic Receptor, Sarcomere

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 4180
• Professor: Glen Pyle

Document Summary

Tropomyosin and troponin overview: tropomyosin and troponin physically prevent myosin and actin from interacting. Troponin: troponin complex has 3 proteins, troponin t (anchors to the tropomyosin, troponin c (for ca++ binding, troponin i (inhibitory element) Tropomyosin are linked, so pushing one out of the way helps move the other tropomyosin out of the way too! This makes it easier for other myosin heads to bind to the actin filament. This effect doesn"t influence the all the tropomyosin and myosin heads, but extends to a couple neighbouring tropomyosins: slide 6. Troponin i moves out of the way when ca++ binds to troponin c. There is still a chance that the myosin head doesn"t bind to the actin: ca++ can unbind, and then we go back to the blocked state, myosin head binds. The tropomyosin is pushed further out of the way: myosin head flexes. The atp molecule in the myosin head is broken.