BIOM 3090 Lecture Notes - Lecture 4: Pancreatic Islets, Beta Cell, Nociception
31 May 2016
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Document Summary
Selectivity is often maintained by therapeutic levels of drugs. At higher doses, drugs can bind non-specifically to other receptors and produce adverse side effects. Drugs need to be able to bind to receptor and interact with the receptor. If the receptor sub-type has a high selectivity, it will have a limited effect (won"t affect other tissues), this is desirable. Note: know drug names, not brand name. Ranitidine: only binds to the h2 receptor, which is specific to the gi tract lining. The effects are widespread in addition to blocking neural signals/pain signals. Example, if lidocaine binds to na channels in the heart, it can cause adverse side effects. Both pacemaker cells and myocardium contain both na and ca channels. By blocking ca in myocardium, won"t see huge effects as this muscle tissue functions mostly with na. Pacemaker cells are more dependent on ca channels, therefore by blocking these, heart rate will be reduced.
