BIOM 3090 Lecture Notes - Lecture 14: Propranolol, Adrenergic, Metoprolol
Document Summary
Sympathomimetics: mimic action of ne/epi (cns, a. Direct: activate receptors directly (one or more subtypes, depending on drug: b. Indirect: increase level of ne at synapse therefore increase activity at multiple receptor subtypes: 2. Cns -> increase psns & decrease sns -> vasodilation: eg. phenylephrine - a1 receptor agonist, activates a1 in blood vessels -> vasoconstriction, baroreceptors detect increase bp -> cns -> Tyramine taken up by transporter and releasing ne: 2. Amphetamine: simulates release of ne similar to tryrsime, reverse transport for ne so pushes it out rather than taking it back up to pre synaptic terminal, activate a and b receptors, do in psns and sns, 3. Adrenergic antagonists - inhibit activity of sns: 1. Block a or b receptors normally activated by ne or epi: 2. Clinical pharmacology of adrenergic drugs: a patients with asthma was prescribed propranolol for the treatment of hypertension.