BIOM 3090 Lecture Notes - Lecture 8: Plasma Protein Binding, Adipose Tissue, Extracellular Fluid
2 Feb 2019
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Physiochemical properties of the drug - drug has to move relatively well between membranes: lipid solubility, size (molecular weight, degree of ionization, 2. Absorption phase (a) then inflection and elimination - cannot see distribution phase. 40% x 70kg = 28 then divide 28 by. 70 and get . 4l/kg intracellular fluid: vd = amount of drug in body (mg) plasma drug [ ] (ug/ml) [drug]plasma: extent to which an organ contributes to drug clearance can be quantified by the extraction ratio, extraction = [drug]in - [drug]out. Cyp2c, cyp2d, cyp3a subfamilies: eg. cyp3a4 3 denotes enzyme gene family, a denotes subfamily and 4 denotes individual gene. Sulphate conjugation (sulfotransferases: phenols and alcohols conjugated to sulphate (so4, e. g. acetamionophen, morphine, 3. Acetylation (n-acetyltransferases: occurs in drugs with -nh2 groups conjugated to coch3, eg. most sulfonaminde antimicrobial drugs, 4. Glutathione conjugation (glutatione s-transferases: epoxides, arene oxidases, conjugated to glutathione (gsh, eg. some anticancer drugs (alkylating agents)
