BIOM 3090 Lecture Notes - Lecture 10: Adrenergic Receptor, Aqueous Humour, Bronchodilator

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Bettina Kalisch

Document Summary

Contraction of smooth muscle in the gi tract and bladder. Constriction of the pupil (miosis) and decreased intraocular pressure through contraction of the ciliary muscle. M3, m5 leads to excitatory responses (through increased ip3 and dag). Activation of m2 or m4 results in inhibitory responses through decreased camp. Symptoms of muscarinic excess (dumbels) are directly related to the effect of muscarinic agonists on receptors. Activation of nm, nn leads to opening of na+ and k+ ion channels. This results in depolarization and subsequent action potentials which opens voltage-gated ca2+ channels leading to activation of intracellular pathways. Release of ne and ach from post-ganglionic neurons in the sns (ne and ach) and the psns (ach only) Dilation of the pupil (myadriasis) through contraction of the dilator muscle in the eye. Decreased secretion of aqueous humor in the eye. Contraction of smooth muscle in the uterus, urinary tract, gi tract and vessels in the skin (vasoconstriction)