BIOM 3010 Lecture Notes - Lecture 1: Trochanter, Diaphysis, Shoulder Girdle

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Structure of the long bones: medullary cavity, filled with yellow marrow in adult, lined in endosteum, double layered membrane surrounding bone except at articular cartilage. Inner cellular layer contains osteoprogenitor cells, osteoblasts, osteoclasts: function: bone growth and repair, out fibrous layer of dense irregular ct attachment of tendons & ligaments, provides route for blood vessels & nerves, separates bone tissue from surrounding tissues. Bone formation and growth: ossification process of converting other tissues to bones, begins around week 6-8 of embryological development, 2 types of ossification occur during embryological formation: Intramembranous ossification: forms flat bones of skull, mandible, clavicle, replacement of mesenchymal membrane with osseous tissue, mesenchymal cells differentiate to osterprogenitor cells which then become osteoblasts, osteoblasts create spongy bone which remodels into compact bone where necessary. Endochondral ossification: most bones formed this way, mesenchyme creates cartilage model, which gets replaced by bone, replacement begins in middle (diaphysis) & follows in ends (epiphyses)

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