BIOM 2000 Lecture Notes - Lecture 26: Pituitary Adenoma, Intracranial Hemorrhage, Benign Tumor
16 Mar 2016
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Document Summary
Main causes of endocrine disorders: elevated or depressed hormone levels: Dysfunction of endocrine gland or endocrine function of cells: Secretory cells are unable to produce or do not obtain an adequate quantity of required hormone precursors. Secretory cells are unable to convert the precursors to the appropriate active form of hormone. Secretory cells may synthesize and release excessive amounts of hormone. Degradation of hormones at an altered rate or they may be inactivated by antibodies before reaching the target cell. Ectopic sources of hormones: failure of target cells to respond to hormone. Number of intracellular receptors may be decreased or may have altered affinity for hormones. Alterations in generation of new messenger rna or absence of substrates for protein synthesis. Decrease in the number of receptors and/or hormone-receptor binding. Impaired receptor structure and function, altered sensitivity to the hormone. Neurological: involved a deficiency of antidiuretic hormone. Nephrogenic: due to kidney or nephron dysfunction caused by an insensitivity to adh.
