BIOL 2400 Lecture Notes - Lecture 12: Cytosine, Glucocorticoid, Histone Acetyltransferase
24 Feb 2015
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Document Summary
Regions of chromosomes that are more intensely stained. Rich in repetitive dna mostly located in centromeres and telomeres. Abnormal gene expression caused by moving a gene from an euchromatic to a heterochromatic region by a translocation or change in orientation by inversion. Can create a mixture of normal and mutant characteristics in the same individual. White mottled allele in drosophila: relocation of the wild-type white gene* to a heterochromatic region by an inversion of the x-chromosome. Heterochromatin spreads into the w+ gene in some cells (white eye) but not others (red eye) * the white gene is responsible for the red eye phenotype. Eyes are white when this gene is mutated. Regulation of gene expression by chromatin structure ( epi = above) A heritable state that is not determined by changes in the sequence of the gene but by chromatin reorganization or dna modification.
