BIOL 1090 Lecture Notes - Lecture 11: Coiled Coil, Nuclear Lamina, Nuclear Pore

• School: University of Guelph
• Department: Biology
• Course: BIOL 1090
• Professor: Terry Van Raay

Document Summary

Nucleus function: storing, replicating, repairing genetic material, expressing genetic material. Condensed chromatid = 1400 nm: dna damage from: uv, chemicals, replication error, metabolism, radiation. Nucleus structure: nuclear envelope: membrane, pores, lamina, nuclear content: chromatin, nucleoplasm, nucleolus. Nuclear envelope: 2 parallel phospholipid bilayers (10 50 nm space, outer nuclear membrane: binds ribosomes, continuous with rough er. Inner nuclear membrane: integral proteins, connects to nuclear lamina: perforated with nuclear pores, functions: Nuclear pore: gateway cytoplasm nucleus, 3500 pores/nucleus, found where inner/outer membranes fuse, complex structure, protein arrangement. Nuclear pore complex: made of nucleoporins (nups) big protein family, octagonal symmetry, basket-like, project into cytoplasm, nucleoplasm, supramolecular complex (large) 15-30 x bigger ribosomes. Cargo stays in nucleoplasm: ran-gtp/importin exit nucleus through nuclear pore complex, gtp gdp. Nucleolus: biggest nucleus structure, function: producing ribosomes, ribosomes of small subunit (read rna) and large (form polypeptide, each subunit of rrna molecules + proteins.