BIOL 1090 Lecture Notes - Lecture 18: Tethering, Nuclear Membrane, Glycosylation
Document Summary
Transport vesicles move soluble proteins and membrane proteins into other compartments or out of the cell. The er is a compartment of flattened sacs and tubules. Rer has ribosomes on the cytoplasmic membrane side. The nuclear envelope, rer, ser are interconnected (contiguous ) Synthesis of integral membrane proteins on membrane-bound ribosomes. Synthesis of transmembrane proteins (except for those in mitochondria and chloroplasts) Membrane and er lumen bud off to form transport vesicles. Transport vesicles fuse to form larger vesicles & interconnected tubules. Material moves from er to golgi and then to the plasma membrane and other compartments. Range from a few to several 100 stacks per cell. Scaffold linked to motor proteins that direct movement of vesicles into and out of the golgi. Cgn acts as the sorting station; sorts protein. Tgn sorts protein into different types of vesicles. Vesicles go to plasma membrane or other intracellular destinations. Proteins are modified step wise as they transverse the golgi.