BIOL 1080 Lecture Notes - Lecture 18: Active Transport, Hypoglycemia, Vo2 Max
5 Apr 2016
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Document Summary
Insluin and glucagon are the main regulatos of metabolism in fed (absorptive) and fasted (post-absoptive) stes. Fed state: insulin dominates insulin increases due to increase in blood glucose and amino acids and feedforward from gut: glucose dependent insulinnotropic peptide (gip) Increase in: glucose uptake, glucose oxidation & synthesis, fat synthesis, protein synthesis. Fasted state: glucagon dominates glucagon increases due to increased sns activity (norepi) and plasma (epinephrine), decrease in blood glucose (sensed by alpha cells) Hyperglycemia (homeostatic overload): type 1 and 2 diabetes. Most serious cases caused by insulin overdose high risk, potentially lethal outcomes. <3 mmol/l: weak, drowsy, confused, clouded vision (eat sugary snack) Vo2 max = maximal oxygn uptake, or maxial aerobic capacity. Walking running: running uses more ffa (free fatty acid) Walking, slow jog): relies more on plasma-derived substrates, particularly ffa, some muscle triglycerides and glycogen beneficial for health (evolutionary med)
