BIOL 1080 Lecture Notes - Lecture 18: Single-Nucleotide Polymorphism, Proinflammatory Cytokine, Senescence
Document Summary
Genetic variation: single nucleotide polymorphisms (snps, don"t occur in coding region. Controls how much of something is made: 10 million snps within the human population. 1 every 300 nucleotides: most frequent source for polymorphic changes, this is not the only source of genetic variation, but this represents a major source that distinguishes one individual from another. Can exercise reduce aging effects: exercise improves aging, polg mice lack mtdna error correction and show increased mtdna mutations and overall advanced aging. Aging is inevitable: but healthy aging can be influenced by lifestyle choices, there is a lot of talk about miracle cures about preventing aging creams, diets, uvb therapy, hormones, etc but there is no holy grail. Caloric restriction: generally, refers to a 20 to 40% reduction. Food restriction without malnutrition: originally reported in 1935 severe food restriction extended, demonstrated in yeast, worms, fruit flies, mice, rabbits, dogs, no conclusive evidence in humans healthy lifespan in rats and monkeys.
