BIOC 3560 Lecture Notes - Lecture 2: Decarboxylation, Citric Acid, Acetyl Group

• School: University of Guelph
• Department: Biochemistry
• Course: BIOC 3560
• Professor: Manfred Brauer

Document Summary

Problem cases for fa degradation: fatty acid with odd number of carbons. Beta-oxidation removes two carbon atoms per cycle and is organized to degrade. 12: beta oxidation will producse both is 3 and cis 4 intermediates, the reaction proceeds just like with one double bond, to produse cis 3, 6. Coa (hmg-coa: acetoacetate is formed by condensing three acetyl coa molecules, then, the reaction proceeds via the key metabolite b-hydyoxy methylglutaryl, alpha beta hydroxybutyrate is formed by reducing acetoacetate, acetone is a biproduct. Smell someones breath, if it smells like acetone (nail polish remover) they are probably ketoacidotic: low glucose levels causes lots of ketone body production, resulting in ketoacidosis. Utilization of ketone bodies: converted back to acetyl coa, d-b-hydroxybutyrate dehydrogenase is required to re-oxidize hydroxybutyrate, acetocetyl-coa is made by b-ketoacyl coa isomerase, in the end, two molecules of acetyl coa are regenerated for tca.