BIOC 2580 Lecture Notes - Lecture 9: T Helper Cell, Stoichiometry, Amine

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Cellular respiration: the process by which cells consume oxygen and produce co2. Citric acid cycle contributes the second stage of cellular respiration. The acetate-moieties derived from catabolism of fats, carbs, and amino acids and oxidizes them to co2: the energy released through these oxidations is conserved in the form of reduced cofactors, nadh and fadh2. Franz knoop studies of the metabolism of citric acid: same guy who discovered beta oxidation, discovered a few reactions to the tca cycle citrate alpha-ketoglutarate . But, the person who deserves the credit for figuring out the citric acid cycle is hans. So, he concluded that these organic acids were linked together in a cyclic, rather than a linear, pathway: 1940 whole cycle was understood. Involvement of acetyl coa was not appreciated until after 1945 when limpann discovered it: krebs had assumed that pyruvate was the feedstock for the cycle. The citric acid cycle affects the complete oxidation of acetate to co2.

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