BIOC 2580 Lecture Notes - Lecture 1: Silica Gel, Acid Dissociation Constant, Amine
28 Oct 2016
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Document Summary
Amino acids consist of an amino group and a carboxylate group. Proteins are made of amino acids joined by amide bonds. The 20 natural amino acids: amino acids share a common backbone, but differ in the side chain, you need to be able to reproduce the structures of the amino acids and know their. 1- and 3- letter codes: you need to be able to associate particular properties with each amino acid, polarity, charge, h-bonding, amino acids can be grouped according to structures or by similar properties. Polar and non-polar properties: polarity is a consequence of atoms having different electronegativity or tendency to hold bonding electrons. O > n > s > c~ h: atoms with similar electronegativity share bonding electrons equally, e. g. c-c, c-h, and are non-polar, different electronegativity in bonding atoms creates unequal bonding with electrons. The ionization state of alpha-carboxylate group at ph 7. Typical pka = 2. 4 +- 0. 5 for amino acid alpha carboxylate.
