ANSC 4650 Lecture Notes - Lecture 14: Immunoglobulin Heavy Chain, Single V, Immunoglobulin Light Chain
23 Feb 2018
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Document Summary
Organization of immunoglobulin and tcr genes: over a billion different b and t cell antigen receptors can be made with only. 500 genes: diversity is achieved by different v region gene rearrangement strategies, gene recombination, somatic mutations, gene conversion, more diversity in immunoglobulins than tcrs therefore the genetic mechanism to make immunoglobulins is more complex. Indels: vj and vdj gene recombination, somatic mutations, combinatorial association, gene conversion, receptor editing. If the successful rearrangement of the (cid:584) light chain occurs then the other. If not successful, the second copy of the (cid:584) gene can be rearranged: pigs prefer (cid:584) light chains. If there are no functional gene products made then the b-cell will undergo apoptosis: if that is not successful then the recombination of the lambda gene will be attempted, species differences, ruminants use lambda light chains. Tcr gene clusters: 3 gene clustres coding the tcrs and the number of v,d,j,c genes in tose clusters vary across species.
