NURS 498 Lecture Notes - Lecture 1: Viral Load, Anal Sex, Reverse Transcriptase
20 Feb 2018
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Document Summary
T helper cells penetrates into the host membrane via endocytosis release viral nucleic acid from viral capsid penetrates into the nucleus synthesis of viral protein and mrna via rt enzyme assembly of new virus release by lysis or budding. 120 interact with uninfected t lymphocytes, neurons, monocytes induce apoptotic cell death of uninfected cells. Synctia= hiv virus fuses with uninfected cell + changes structure of cell forms large. High viral load first 2 to 6 weeks/ transition from hiv to. Can have high viral load + sero (undetectable) Depletion of cd4+ cells increases immune system becomes more. Pts may manifest one of several diffing conditions: Early symptoms: fatigue, fever, muscle aches, headache (flu-like) Asymptomatic (may last as long as 10 years) Labs: wbc, cd4 progressively decreases (<200), viral load increases, anti-specific antibodies (need > 40- Indigenous, immigrants/refugees, gay/ bisexual, women, children, young people, use inject drugs, use substances, street-involved, sex workers, prisoners, living with hiv, older adults, transsexual (aka.
