CMMB 421 Lecture Notes - Lecture 21: Ebola Vaccine, Ebola Virus Disease, Filoviridae
28 Dec 2019
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Envelope virus: part of cellular membrane wrapping around capsid and matrix. Virion carries polymerase that makes +rna, then does transcription, and copies of -rna to get progeny genomes. Typical for rna virus: everything happens in cytoplasm of infected cell. Viral membrane interesting this is that there are viral proteins (vp40) Inside lipid bilayer are viral proteins (glycoproteins) Interesting thing about proteins: if you express the matrix and glycoproteins alone in eukaryotic cell, it will form a virus particle which looks like an ebola virus (non infectious) but does not have genome. This is important because it has authentic surface structure of virus, that can be used in vaccine development. There are 2 types of antibodies: non neutralizing and virus neutralizing, we want viral neutralizing antibodies in host. Virus neutralizing antibodies will prevent an incoming virus from infecting our body. In most cases, these antibodies interfere the area where virus tries to attach to its corresponding cellular receptor on the host.
