CMMB 421 Lecture Notes - Lecture 13: Crispr, Infection, Bacteriophage
28 Dec 2019
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Document Summary
Archaeal viruses exhibit great variability in morphology and are phylogenetically very diverse. Temperate archaeoviruses exist, and it is common to have viruses that replicate without lysis. Those that infect extremophiles have adaptations to low ph, high temperature etc. and can have interesting exit strategies. Since many mesophilic archaea have not been cultivated we have only scratched the surface in terms of their study. Bacteria (and archaea) have evolved a number of sophisticated systems to protect themselves from viruses. These include, but are not limited to, lysogeny, restriction- modification systems, abortive infection mechanisms, and crispr-cas systems. Phages, in turn, have evolved mechanisms to overcome these. If you provide a template with a change in ds, repair system will replace it, this will create a mutation. You have to put template with different version of the gene to get mutation. System is good for making mutations in lytic bacteriophages.
