PMCOL305 Lecture Notes - Lecture 9: Organochloride, Tetrachloroethylene, Isobutylene
11 Oct 2016
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Mech of action gaba, glycine, ach and glutamate rs. What are they? (all structurally different; similar effects) Instant alcohol-like effects euphoria, dizziness, disinhibition, impaired judgment, recklessness. Lasts 15-45 mins followed by one to two hours of drowsiness. Motor excitation at low levels (inhib of inhibitory circuits), sedates or anesthetizes at high lvls. High lvls can lead to hallucinations, coma and death. They are unique among depressant agents in producing hallucinations. Aliphatic (straight chain) hydrocarbons: isobutene, n-butane, hexane and. Aromatic (ring structure) hydrocarbons: toluene and xylene often found in gasoline. Chlorinated hydrocarbons: tetrachloroethylene, trichloroethylene dry cleaning supplies, fabric protectors. Soak a cloth and hold it over face. Can cause asphyxiation, lung damage (from pressure in canisters), hypoxia. Delivered quickly to brain highly lipophilic but leave just as quickly need constant admin. Rate determined for most of the volatile substances by diffusion down a [ ] gradient.
