PHYSL405 Lecture Notes - Lecture 15: Intravitreal Administration, Pharmacotherapy, Visual Angle
7 Nov 2016
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Amd is a chronic dege(cid:374)e(cid:396)ative disease that p(cid:396)i(cid:373)a(cid:396)il(cid:455) affe(cid:272)ts (cid:272)ho(cid:396)io(cid:272)apilla(cid:396)is, b(cid:396)u(cid:272)h"s membrane, retinal pigment epithelium (rpe) and photor cells. Amd is the most common cause of irreversible visual loss over 65 yo in west: 20-30% of population is affected over 75 yo (1 in 10 at 65 and 1 in 4 at 75 = exponential) Outer retina = very metabolically active (outer retina = photoreceptors) Only way we can see = stop dark current = outcome of phototransduction. Cones constantly have a dark current (do not desensitize) (cid:862)light e(cid:374)ough to (cid:271)e (cid:271)li(cid:374)d(cid:863) is e(cid:395)ual to phototo(cid:454)i(cid:272)it(cid:455) (cid:894)(cid:271)li(cid:374)d if sta(cid:396)e at su(cid:374) (cid:374)ot due to desensitizing cone (always maintain ability to circulate dark current) but killing of cells. Phototransduction = extremely rapid event; only poosible due to fluidity of. Membrane of os disks = due to dha (50% of fatty acids in os = dha) Dha = most oxidizable fa in whole living kingdom (from uni- to multi- cellular)
