PHYSL210A Lecture Notes - Lecture 14: Memory T Cell, Cytotoxic T Cell, Cholera Toxin
1 May 2019
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Document Summary
Memory cells: when body faces the same antigen, memory cells divide and produce antibodies. Antibodies are made in the blood for humoral immunity- some chemical substance giving us chemical protection mostly against bacterial infection. Antibodies bind to their specific antigens to form immune complexes. Once the antibody antigen complex is formed, we can use free antibody molecule for opsonization, activate inactive compliment proteins (recruit macrophages and neutrophils). Very important task of humoral immunity: binding and neutralization of toxins. Once toxic molecules bind to receptors in cell, they get in and make you sick eg. cholera toxin. As toxin is inside the body, the adaptive immune system kicks in and produces antibodies. Antibodies in circulation bind these toxins and produce immune complexes. As a result, they are not making these molecules available to the receptors of the cell- removal of toxin effect/ neutralizing toxic effect. Ultimately, immune complexes are engulfed by macrophages, and chop it up into small little pieces.
