NURS 224 Lecture Notes - Lecture 28: Mesolimbic Pathway, Daminozide, Neuroleptic Malignant Syndrome
4 Nov 2020
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Psychosis phases: prodrome, acute: clear psychotic symptoms, recovery. Present for a significant portion of 1 month and continues for 6 months. Persecutory delusions: belief that one is being watched, ridiculed, harmed, or plotted against. 5 types: paranoid, disorganized, catatonic, undifferentiated, residual. Risk factors: perinatal period stress, obstetrical complications and genetics. Often begins in adolescence to early adulthood. Can suffer from disordered water balance/water toxicity. Positive symptoms: excessive dopamine in the mesolimbic tract. Negative symptoms: hypo-activity of dopamine in the mesolimbic tract. Alogia: reduced fluency and productivity of thought and speech. Avolition: withdrawal and inability to initiate o persist in goal directed activity. Ambivalence: strong emotions leading to the inability to make decisions. Echopraxia: involuntary imitation of another person" movement and gestures. Waxy flexibility: posture held in an odd or unusual fixed position for extended periods of time. Hypofrontality: reduced blood flow and glucose metabolism in the prefrontal cortex. Expressed emotion (ee): indicative of overinvolvement and likeliness to make negative comments.
