NURS 216 Lecture Notes - Lecture 6: Vasodilation, Vasomotor Center, Prodrug
23 Sep 2019
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Ca2+ influx blocked = smooth muscle contraction. Specificity: cardiac, arterial and coronary artery muscle. Complete health history (include allergies and drug history) Neurological status and level of consciousness (loc) Treatment: calcium channel blockers (verapamil, diltiazem), beta blockers (propranalol, Blocks the sympathetic nervous system at various adrenergic receptors. Metoprolol (beta 1, and in high doses beta 2) Increased myocardial activity and increased heart rate. Stimulate/agonise cns alpha 2 receptors in the vasomotor centre directly. Decreases the presynaptic ca levels which inhibits the release of norepinephrine. Cell damage to mechanical stress (hemodynamic hypertension), immune response (inflammatory sequelae from cytokines, leukocytes resulting from a high cholesterol level) and oxidative stress (circulation of free radical oxygen) Foam cells : apoptosis of foam cells - lipid residue stays. First occurs in the aorta and coronary arteries. Caused by free radicals (reactive molecules with unpaired electrons)
